ACS Organic Chemistry Exam Study Guide 2027–2028 | Organic Chemistry Final Exam Prep, 200 Practice Questions (PDF)

Prepare for the ACS Organic Chemistry Exam, the standardized final exam from the American Chemical Society's Examinations Institute that many colleges give at the end of a two-semester organic chemistry course. This study guide follows the chapter topics of the official ACS organic chemistry study guide and teaches the reasoning the exam rewards: predicting the major product, choosing the right reagent, ranking acidity and reactivity, assigning stereochemistry and matching compounds to spectra.

What's Inside

• Exam overview: the full-year, First-Term and Brief versions, item counts and timing, the paper booklet and answer sheet, calculator and reference-data rules, and how national percentile norms work (there is no passing score)

• Structure and bonding: Lewis structures, formal charge, hybridization, resonance, intermolecular forces, conformations, Newman projections and the cyclohexane chair

• Nomenclature, functional groups and degrees of unsaturation

• Isomers and stereochemistry: R/S, E/Z, Fischer projections, enantiomers, diastereomers, meso compounds, optical activity and enantiomeric excess

• Acids and bases: pKa values, equilibrium direction and the structural factors that control acidity and basicity

• Reactions: SN1, SN2, E1 and E2; additions to alkenes and alkynes; alcohols, ethers and epoxides; radical reactions; conjugated dienes and the Diels-Alder reaction; aromaticity; electrophilic and nucleophilic aromatic substitution; aldehydes, ketones, carboxylic acids and derivatives; enols, enolates, aldol, Claisen, Michael and Robinson reactions

• Spectroscopy and spectrometry: mass spectrometry, IR, 1H and 13C NMR and UV-vis, with combined structure problems

• Multistep synthesis, retrosynthesis and applications: carbohydrates, amino acids, lipids and polymers

• Diagrams of reaction energy profiles, Newman projections, the chair, SN2 inversion, a Fischer projection, Frost circles and Diels-Alder, IR and NMR range charts, plus 168 quick-reference tables

• Worked examples, Exam Tips, Common Traps and Memory Aids in every chapter

• Study schedules (4, 8 and 12 weeks), FAQs and test-taking strategies

• 2 practice tests of 100 questions each (200 questions total), four options per question like the real exam, covering every topic area, with a complete answer key and an explanation for every question

Format

• Instant digital download (PDF), 8.5 × 11 in

• Clickable table of contents

• Print it or study on a tablet, laptop or phone

Please note: This is a digital product. No physical item will be shipped.

This is an independent study resource and is not affiliated with or endorsed by the American Chemical Society (ACS) or the ACS Division of Chemical Education Examinations Institute.