MTEL Biology (66) Study Guide 2027–2028 | Massachusetts Biology Teacher License Prep, 200 Questions (PDF)

Prepare for MTEL Biology (66), the Massachusetts Tests for Educator Licensure subject matter test for the Massachusetts biology teaching license. The 13 sections follow the official subareas and objectives, from molecules and cells to ecosystems, heredity and evolution, and both open-response assignment types are taught step by step with model responses.

What's Inside

• Exam overview: 100 multiple-choice questions and 2 open-response assignments, 4 hours of testing time, the 80/20 test design, the 240 qualifying score, the $139 fee and the 30-day retake rule

• Molecules: water, bonding, pH and buffers, macromolecules, enzymes, ATP, photosynthesis and cellular respiration

• Organisms: cells and membranes, the cell cycle, cancer and stem cells, diversity of life, cell communication and human anatomy and physiology

• Ecosystems: populations, communities, biomes, energy flow, matter cycles, human impacts and climate change

• Heredity and evolution: molecular genetics, biotechnology, meiosis, Mendelian and non-Mendelian inheritance, pedigrees, natural selection, Hardy-Weinberg and cladograms

• Science and engineering practices, experimental design, data and graphs, lab safety and teaching a diverse group of students

• The two open-response assignments: planning templates, scored model and weaker responses, and practice assignments

• Diagrams and graphs (cell cycle, membrane transport, energy pyramid, Punnett square, cladogram, growth curves and more) and 153 quick-reference tables

• Study schedules, FAQs and test-taking strategies

• 2 practice tests of 100 questions each, 200 questions total, with a complete answer key and an explanation for every question

Format

• Instant digital download (PDF), 8.5 × 11 in

• Clickable table of contents

• Print it or study on a tablet, laptop or phone

Please note: This is a digital product. No physical item will be shipped.

This is an independent study resource and is not affiliated with or endorsed by the Massachusetts Department of Elementary and Secondary Education, the Massachusetts Tests for Educator Licensure program or Pearson.